After introductions and small talk this would be the time to ask a question to start the interview on the right foot.  Say it in your own words but this question sets up the interview for you:

“What kind of person are you looking for and what are you looking for this new person to do for the first 6 months to a year?”

This now gives you insight to what the interviewer is looking for.  Your response should be catered around what they have told you.  You need to make sure that when you answer to be specific and that you use real examples of your past to back it up.

So many people base their interview on a job description rather than the interviewer.  Job descriptions are just a guide to what the company has posted and perhaps the hiring authority or manager is looking for something more specific.  That is why when meeting with multiple people you should ask that same question.

Some other questions that you should consider to ask towards the end of the interview would be:

What are some of the departmental goals?

What are some of the goals of the organization overall?

Where do you see this company in the next 5 years?

What’s the upside potential of this position?

Remember that an interview is a two way street.  You need to find out the questions that are important to you so that you can determine if you want to work there.  If you are working with a recruiter you want to stay away from salary and benefit questions and leave that for your recruiter to work out for you.

For more:  Interview preparation